Lysine-proline-valine (KPV) is a C-terminal peptide fragment of α-melanocyte stimulating hormone. KPV is a small peptide with a short but action-packed molecular structure. The sequence of lysine, proline, and valine appears to endow it with specific physicochemical characteristics, such as stability and solubility, which might contribute to its functional role in certain organisms. The synthesis of KPV is believed to be achieved through conventional peptide synthesis methods, including solid-phase peptide synthesis (SPPS), which ensures the precise assembly of its amino acid sequence.
KPV is a potent anti inflammatory peptide that has shown promise in a number of disease conditions. The most active research is in the treatment of inflammatory bowel disease where the peptide has showed substantial promise. KPV has been shown in animal studies to be safe and effective when administered orally, intravenously, subcutaneously and transdermal. Research in wound healing also reveals that KPV and other alpha MSH derivatives may offer a host of benefit